This test requires a blood draw, so please ensure you can refer to a phlebotomist in the clients area before you order this test.

(Nordic Laboratories accept no cost or claims related to any phlebotomy services in the event of sample rejection or failure for any reason. By ordering this, or any test, requiring phlebotomy services, you accept any inherent risk and any associated costs.)

Elispot looks at the T cell response and IGG/IGM looks at B cells/Antibodies. 

Some people don't produce antibodies and have a more active T cell response. 

In an ideal world to assess an infection, a practitioner should look at both sides of the immune system response, in other words, Eli-spot for the T cells/cellular response and IGG/IGM for humoral/B cell/antibody response.

To check for an active infection with the T cells, the Elispot is recommended.

Elispot For current active infections with:

Borrelia burgdorferi, Anaplasma, Ehrlichia, Chlamydia pneymoniae, Chlamydia trachomatis, Yersinia, Epstein-Barr Virus, Cytomegalovirus, Babesia, Bartonella, Mycoplasma and Varicella zoster virus .

• This test is highly sensitive and can detect even one single Borrelia burgdorferi-reactive T-cell. This is one of the most sensitive cellular assays available, as detection levels can be as low as one cell in 100,000. .
• The Elispot reflects chronic and recent Borrelia burgdorferi infections. .
• It is between 20 and 200 times more sensitive than a conventional ELISA test.
• The EliSpot displays similar sensitivity to an RTPCR (Real Time PCR) analysis, but detects the secreted protein instead of the mRNA (messenger RNA). .

This test can be helpful in monitoring therapeutic treatments. It should become negative about 4 to 8 weeks after the completion of an effective therapy.

The Epstein-Barr Virus Elispot-LTT test is designed to detect the Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), which is of the herpes family, and is one of the most common viruses in humans.

The Epstein-Barr virus is best known as the cause of infectious mononucleosis (glandular fever). However, it s also associate with particular forms of cancer, such as Hodgkin’s lymphoma, Burkitt’s lymphoma, nasopharyngeal carcinoma, and central nervous system lymphomas, associated with HIV.

Elispot-LTT tests:

The result of the EliSpot test indicates current celluar activity against Epstein-Barr-Virus (EBV).  

• EBV-lytic antigen: sign for replication of infectious EBV virions
• EBV-latent antigen: sign for EBV latency with no production of infectious EBV virions

Overview

Latent phase is the so called sleeping phase, which can be reactivated = past infection

Lytic phase reflects an activity phase = current replication of the virus

Results can show all constellations; latent + lytic positive or both negative, or just lytic or latent positive.

Practical

3 x CPDA tubes

This test requires a blood draw, so please ensure you can refer to a phlebotomist in the clients area before you order this test.

(Nordic Laboratories accept no cost or claims related to any phlebotomy services in the event of sample rejection or failure for any reason. By ordering this, or any test, requiring phlebotomy services, you accept any inherent risk and any associated costs.)